Volume 32, Number 5, December 1997
|Page(s)||625 - 636|
|Published online||17 June 2005|
Interaction uranium-cellule cible : exemple de la transformation de particules d'UO4 dans le macrophage alvéolaire
Interactions between uranium and target cells: Example of UO4 particle transformation within alveolar macrophages
Institut de Protection et de Sûreté Nucléaire, Département de la santé de l'Homme et de Dosimétrie, Service de Dosimétrie, IPSN - BP 38 - F-26701 Pierrelatte Cedex, France.
2 CNRS, Université de Paris XI, Laboratoire de Physique des Solides, F-91405 Orsay Cedex
Interactions between uranium and target cells: Example of UO4 particle transformation within alveolar macrophages. Interactions between uranium and target cells: examples of UO4 particle transformation within alveolar macrophages. The understanding of the mechanisms involved in the in vivo dissolution of inhaled particles is necessary to improve the model for determining the parameters. With that perspective, the intracellular transformation of UO4 particles has been investigated. Indeed, very few is known about this compound encountered in the nuclear fuel cycle. After instillation of UO4 particles in rats, alveolar macrophages and lung tissues have been observed. The particles break up very quickly in ultrafine particles and in some cases, this mechanism is accompanied by the formation of uranyl phosphate needles. This phenomenon takes place at very early stage, i.e., within the first 24 hours after the instillation. Particles phagocytised by macrophages in vitro have been observed after inclusion of the cells directly on the culture dish. These observations have confirmed the corrosive action exerted by the macrophages on the UO4 particles.
Key words: uranium oxide / biological effects / lungs, rodent
© EDP Sciences, 1997
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.