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Table 1
Summary of the top 15 biological processes from gene set enrichment analysis.
| Process | Genes in query set | Total genes in genome | FDR corrected hypergeometric P value* | Genes |
|---|---|---|---|---|
| Positive regulation of gene expression (BP) | 10 | 104 | 6.80E-07 | SLC6A4, CD44, TWIST1, PLAUR, AVPR2, NCOA3, MYLK2, CSF2, CALR, KIT |
| Blood coagulation (BP) | 18 | 457 | 9.60E-07 | THPO, PPBP, L1CAM, PROS1, IFNA1, PIK3CA, SERPINC1, SERPINB2, PLAUR, TP53, F11R, F8, PIK3CG, PIK3CB, TIMP1, BCAR1, SERPINE1, PIK3R5 |
| Signal transduction (BP) | 29 | 1176 | 1.22E-06 | RASGRF1, NR2E3, KCNIP3, OPTN, NRP1, APOL3, COL4A3BP, PIK3CA, NR1I2, ARTN, PLAUR, ADCY3, ARL2BP, ESR1, GJA1, ARFRP1, HINT1, PIK3CB, OPN1LW, KIT,LTBR, PIK3CD, CXXC5, BCAR1, ANGPTL4, PAG1, CREBBP, IMPA1, PDGFRB |
| Transport (BP) | 19 | 604 | 5.10E-06 | RBP5, NCBP1, DBI, CLCN2, SLC25A47, APOL3, COL4A3BP, SERPINA5, CACNA1B, SLC25A33, RBM8A, GJA1, SLC6A8, CNGB1, MTCH1, SLC25A32, SLC12A3, PARP4, MTCH2 |
| Axon guidance (BP) | 14 | 307 | 5.25E-06 | L1CAM, COL9A1, NRP1, FARP2, SCN8A, ARTN, COL5A2, PTPRC, PTPRA, CACNA1F, SEMA3A, COL9A2, MYL6, COL5A1 |
| Cell adhesion (BP) | 18 | 556 | 6.55E-06 | L1CAM, COL9A1, AMBP, CD44, DSC3, NRP1, DSC2, RPSA, F11R, HABP2, F8, CTNND1, PIK3CB, COL11A2, LAMC2, BCAR1, COL5A1, COMP |
| Platelet activation (BP) | 11 | 234 | 7.60E-05 | THPO, PPBP, SAA1, PROS1, PIK3CA, F8, PIK3CG, PIK3CB, TIMP1, SERPINE1, PIK3R5 |
| Cell junction assembly (BP) | 7 | 90 | 0.000247 | F11R, SFTPA2, JUP, CTNND1, SFTPA1, LAMC2, KRT5 |
| Negative regulation of apoptotic process (BP) | 11 | 272 | 0.000257 | CD44, PLAUR, TP53, LEP, PIK3CG, CFLAR, CSF2, TIMP1, ANGPTL4, SERPINE1, JTB |
| Intracellular receptor mediated signaling pathway (BP) | 5 | 32 | 0.000277 | NR0B1, NR2E3, NR1I2, PPARA, PTGER3 |
| Negative regulation of transcription from RNA polymerase II promoter (BP) | 13 | 416 | 0.000341 | NR0B1, KCNIP3, TWIST1, FOXD3, PPARA, TP53, LEP, JUP, IKZF1, ATN1, CALR, TCEAL1, CREBBP |
| Regulation of proteolysis (BP) | 5 | 37 | 0.000359 | SERPINA5, SERPINC1, SERPINB2, PLAUR, SERPINB3 |
| Acute-phase response (BP) | 5 | 37 | 0.000359 | SAA1, F8, REG3G, REG3A, SAA4 |
| Negative regulation of endopeptidase activity (BP) | 6 | 67 | 0.00039 | PROS1, SERPINA5, SERPINC1, SERPINB2, SERPINE1, SERPINB3 |
| Cell migration (BP) | 7 | 105 | 0.000432 | NRP1, JUP, ATN1, BCAR1, COL5A1, PARP9, PDGFRB |
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