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Table 2
Summary of the KEGG pathways from gene set enrichment analysis.
| Process | Genes in query set | Total genes in genome | FDR corrected hypergeometric P value* | Genes |
|---|---|---|---|---|
| Focal adhesion | 13 | 197 | 5.22E-10 | COMP, PIK3R5, PIK3CA, PIK3CB, BCAR1, MYLK2, COL5A2, PIK3CD, PDGFRB, LAMC2, RASGRF1, COL5A1, PIK3CG |
| Jak-STAT signaling pathway | 10 | 153 | 8.00E-08 | PIK3R5, PIK3CA, PIK3CB, IFNA1, LEP, CSF3, PIK3CD, PIK3CG, CREBBP, CSF2 |
| Complement and coagulation cascades | 7 | 65 | 2.97E-07 | PLAUR, F8, PROS1, SERPINE1, SERPINC1, SERPINA5, CD46 |
| Pathways in cancer | 12 | 324 | 3.65E-07 | PIK3R5, KIT, PIK3CA, PIK3CB, PIK3CD, PDGFRB, LAMC2, JUP, PIK3CG, CREBBP, TP53, PTGS2 |
| Apoptosis | 7 | 86 | 1.19E-06 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG, CFLAR, TP53 |
| Non-small cell lung cancer | 6 | 53 | 1.24E-06 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG, TP53 |
| Chemokine signaling pathway | 9 | 186 | 1.38E-06 | PIK3R5, PIK3CA, PIK3CB, BCAR1, ADCY3, PIK3CD, PPBP, PIK3CG, CCL27 |
| T cell receptor signaling pathway | 7 | 107 | 3.88E-06 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PTPRC, PIK3CG, CSF2 |
| VEGF signaling pathway | 6 | 75 | 6.29E-06 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PTGS2 |
| Phosphatidylinositol signaling system | 6 | 76 | 6.57E-06 | IMPA1, PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG |
| Fc epsilon RI signaling pathway | 6 | 77 | 6.62E-06 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG, CSF2 |
| Natural killer cell mediated cytotoxicity | 7 | 125 | 7.87E-06 | PIK3R5, PIK3CA, PIK3CB, IFNA1, PIK3CD, PIK3CG, CSF2 |
| Cytokine-cytokine receptor interaction | 9 | 259 | 1.31E-05 | KIT, IFNA1, LEP, CSF3, LTBR, PDGFRB, PPBP, CSF2, CCL27 |
| mTOR signaling pathway | 5 | 52 | 1.59E-05 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG |
| Fc gamma R-mediated phagocytosis | 6 | 92 | 1.61E-05 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PTPRC, PIK3CG |
| Regulation of actin cytoskeleton | 8 | 209 | 2.11E-05 | PIK3R5, PIK3CA, PIK3CB, BCAR1, MYLK2, PIK3CD, PDGFRB, PIK3CG |
| Inositol phosphate metabolism | 5 | 57 | 2.32E-05 | IMPA1, PIK3CA, PIK3CB, PIK3CD, PIK3CG |
| Toll-like receptor signaling pathway | 6 | 101 | 2.55E-05 | PIK3R5, PIK3CA, PIK3CB, IFNA1, PIK3CD, PIK3CG |
| B cell receptor signaling pathway | 5 | 75 | 8.07E-05 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG |
| Insulin signaling pathway | 6 | 133 | 0.000111 | PIK3R5, PIK3CA, PIK3CB, HK3, PIK3CD, PIK3CG |
| ECM-receptor interaction | 5 | 84 | 0.00013 | COMP, COL5A2, LAMC2, CD44, COL5A1 |
| ErbB signaling pathway | 5 | 87 | 0.000151 | PIK3R5, PIK3CA, PIK3CB, PIK3CD, PIK3CG |
| Calcium signaling pathway | 6 | 175 | 0.000462 | MYLK2, CACNA1B, ADCY3, PTGER3, PDGFRB, CACNA1F |
| MAPK signaling pathway | 5 | 262 | 0.016872 | CACNA1B, PDGFRB, RASGRF1, TP53, CACNA1F |
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