| Issue |
Radioprotection
Volume 53, Number 3, July-September 2018
|
|
|---|---|---|
| Page(s) | 207 - 217 | |
| DOI | https://doi.org/10.1051/radiopro/2018024 | |
| Published online | 21 June 2018 | |
Article
Monte Carlo study of dose distribution improvement by skin-shielding layer design in boron neutron capture therapy for non-small-cell lung cancer
1
Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics,
Nanjing
210016, P.R. China
2
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,
Nanjing
210016, P.R. China
* Corresponding author: tanxiaobin@nuaa.edu.cn
Received:
19
April
2017
Accepted:
25
May
2018
The skin dose exceeds its dose limitation easily in using an accelerator-based neutron source for non-small-cell lung cancer (NSCLC) with boron neutron capture therapy (BNCT). To solve this problem, design analyses in materials and thicknesses of skin-shielding schemes were investigated through Monte Carlo method. Two skin-shielding schemes were better and could reduce the healthy organ dose: scheme A (0.1 cm-thick thermoplastic with 96%-enriched 6LiF), and scheme B (0.6 cm-thick lithium carbonate). Scheme B with shorter irradiation time was the optimized schemes to improve the dose distribution of BNCT for NSCLC.
Key words: BNCT / non-small-cell lung cancer / skin dose / dose assessment / Monte Carlo method
© EDP Sciences 2018
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