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Table 1
Selenium and selenium-containing compounds and metabolites to function as valuable radioprotective adjuvants. Se-L-Met, Seleno-L-Methionine; Eb, Ebselen; Se-NPs, selenium nanoparticles.
| Type of Selenium Seupplementation | Dosage of Selenium | Object | Dosage of Radiation | Timing | Author |
|---|---|---|---|---|---|
| Selenium | 800 IU for selenium group and 50 mg for combined group | human | 2 Gy of X-rays | before radiation | Rostami et al. (2016) |
| 0.8 mg/kg body weight | mice | 2 Gy of γ irradiation | before radiation | H Bagheri et al. (2019) | |
| Se-L-Met | 10 µM | RKO cells | UV-radiation | before radiation | Fischer et al. (2006) |
| 100 µg/kg body weight/day*30d | mice | UV-radiation | before radiation | Guo, Guo, and Liu (2020) | |
| 4 mg/kg body weight | rats | 2 Gy of γ irradiation | before radiation | H Bagheri et al. (2017) | |
| 4 mg/kg body weight | rats | 15 Gy of γ irradiation | 1 day before and 3 consecutive days after radiation | Amini et al. (2018) | |
| 4 mg/kg body weight | rats | 15 Gy of γ irradiation | 1 day before and 5 consecutive days after radiation | Amini et al. (2019) | |
| Eb | 5 µM | U937 cells | 2/20 Gy of γ irradiation | before radiation | Tak and Park (2009) |
| 10 mg/kg body weight/day*14d | mice | 8 Gy of γ irradiation | before radiation | ||
| Sodium Selenite | 50 nM | CHEK-1 cells | 2 Gy of X-rays | before radiation | Puspitasari et al. (2017) |
| 0.8 mg/kg body weight | rats | 15 Gy of X-rays | before radiation | Yamasaki et al. (2019) | |
| cumulative dose of 17 mg | human | Depending on the individual treatment plan | during the whole radiotherapy | Muecke et al. (2010,2014) | |
| 4µg/kg body weight | mice | 5/8 Gy of γ radiation | before and after radiation | Verma, Kunwar, and Indira Priyadarsini (2017) | |
| Sodium Selenite and Se-L-Met | 100 µg of (atomic) selenium/d*21w | rats | 10 Gy of X-rays | after radiation | Sieber et al. (2009) |
| 150 or 200µg/d*4m | Sieber et al. (2011) | ||||
| Sodium Selenite and Se-NPs | 0.1 mg/kg body weight*14d | mice | 2/8 Gy of γ irradiation | before and after radiation | Karami et al. (2018) |
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