Free Access
Volume 46, Number 4, Octobre-Décembre 2011
Page(s) 493 - 510
Section Articles
Published online 16 December 2011
  • Bentzen S.M.,Dorr W.,Anscher M.S.,Denham J.W.,Hauer-Jensen M.,Marks L.B.,Williams J. (2003) Normal tissue effects: Reporting and analysis, Semin. Radiat. Oncol. 13, 189-202. [CrossRef] [PubMed] [Google Scholar]
  • Bolling T., Willich N. (2010) Long-term overall and cardiovascular mortality after childhood cancer: The problem of retrospective estimated radiation doses, J. Clin. Oncol. 28, e436; author reply e437-438. [CrossRef] [PubMed] [Google Scholar]
  • Cheng S.W.,Wu L.L.,Ting A.C.,Lau H.,Lam L.K.,Wei W.I. (1999) Irradiation-induced extracranial carotid stenosis in patients with head and neck malignancies, Am. J. Surg. 178, 323-328. [CrossRef] [PubMed] [Google Scholar]
  • Chou C.H.,Chen S.U.,Cheng J.C. (2009) Radiation-induced interleukin-6 expression through mapk/p38/nf-kappab signaling pathway and the resultant antiapoptotic effect on endothelial cells through mcl-1 expression with sil6-ralpha, Int. J. Radiat. Oncol. Biol. Phys. 75, 1553-1561. [CrossRef] [PubMed] [Google Scholar]
  • Clarke M., Collins R., Darby S., Davies C., Elphinstone P., Evans E., Godwin J., Gray R., Hicks C., James S. and others (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials, Lancet 366, 2087-2106. [CrossRef] [PubMed] [Google Scholar]
  • Coon A.B.,Dickler A.,Kirk M.C.,Liao Y.,Shah A.P.,Strauss J.B.,Chen S.,Turian J.,Griem K.L. (2010) Tomotherapy and multifield intensity-modulated radiotherapy planning reduce cardiac doses in left-sided breast cancer patients with unfavorable cardiac anatomy, Int. J. Radiat. Oncol. Biol. Phys. 78, 104-110. [CrossRef] [PubMed] [Google Scholar]
  • Cottin Y.,Kollum M.,Kolodgie F.D.,Chan R.C.,Kim H.S.,Vodovotz Y.,Virmani R.,Waksman R.,Yazdi H. (2001) Intravascular radiation accelerates atherosclerotic lesion formation of hypercholesteremic rabbits, Cardiovasc. Radiat. Med. 2, 231-240. [CrossRef] [PubMed] [Google Scholar]
  • Darby S.C.,McGale P.,Taylor C.W.,Peto R. (2005) Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: Prospective cohort study of about 300,000 women in us seer cancer registries, Lancet Oncol. 6, 557-565. [CrossRef] [PubMed] [Google Scholar]
  • Demirci S.,Nam J.,Hubbs J.L.,Nguyen T.,Marks L.B. (2009) Radiation-induced cardiac toxicity after therapy for breast cancer: Interaction between treatment era and follow-up duration, Int. J. Radiat. Oncol. Biol. Phys. 73, 980-987. [CrossRef] [PubMed] [Google Scholar]
  • Dorresteijn L.D.,Kappelle A.C.,Boogerd W.,Klokman W.J.,Balm A.J.,Keus R.B., van Leeuwen F.E.,Bartelink H. (2002) Increased risk of ischemic stroke after radiotherapy on the neck in patients younger than 60 years, J. Clin. Oncol. 20, 282-288. [CrossRef] [PubMed] [Google Scholar]
  • Dorresteijn L.D.,Kappelle A.C.,Scholz N.M.,Munneke M.,Scholma J.T.,Balm A.J.,Bartelink H.,Boogerd W. (2005) Increased carotid wall thickening after radiotherapy on the neck, Eur. J. Cancer 41, 1026-1030. [CrossRef] [PubMed] [Google Scholar]
  • Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) (2000) Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: An overview of the randomised trials. Early breast cancer trialists’ collaborative group, Lancet 355, 1757-1770. [Google Scholar]
  • Fajardo L.F. (2005) The pathology of ionizing radiation as defined by morphologic patterns, Acta Oncol. 44, 13-22. [CrossRef] [PubMed] [Google Scholar]
  • Fossa S.D., Gilbert E., Dores G.M., Chen J., McGlynn K.A., Schonfeld S., Storm H., Hall P., Holowaty E., Andersen A. and others (2007) Noncancer causes of death in survivors of testicular cancer, J. Natl. Cancer. Inst. 99, 533-544. [CrossRef] [PubMed] [Google Scholar]
  • Gaugler M.H. (2005) A unifying system: Does the vascular endothelium have a role to play in multi-organ failure following radiation exposure? BJR Suppl. 27, 100-105. [CrossRef] [PubMed] [Google Scholar]
  • Gaugler M.H.,Drouet F.,Krempf M. (2011) radiotherapy and atherosclerosis: Current data and issues, Med. Sci. (Paris) 26, 740-746. [CrossRef] [EDP Sciences] [Google Scholar]
  • Gaugler M.H.,Squiban C., van der Meeren A.,Bertho J.M.,Vandamme M.,Mouthon M.A. (1997) Late and persistent up-regulation of intercellular adhesion molecule-1 (icam-1) expression by ionizing radiation in human endothelial cells in vitro, Int. J. Radiat. Biol. 72, 201-209. [CrossRef] [PubMed] [Google Scholar]
  • Gaugler M.H.,Vereycken-Holler V.,Squiban C.,Aigueperse J. (2004) Pecam-1 (cd31) is required for interactions of platelets with endothelial cells after irradiation, J. Thromb. Haemost. 2, 2020-2026. [CrossRef] [PubMed] [Google Scholar]
  • Gaugler M.H.,Vereycken-Holler V.,Squiban C.,Vandamme M.,Vozenin-Brotons M.C.,Benderitter M. (2005) Pravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responses, Radiat. Res. 163, 479-487. [CrossRef] [PubMed] [Google Scholar]
  • Gerber T.C.,Carr J.J.,Arai A.E.,Dixon R.L.,Ferrari V.A.,Gomes A.S.,Heller G.V.,McCollough C.H.,McNitt-Gray M.F.,Mettler F.A. et al. (2009) Ionizing radiation in cardiac imaging: A science advisory from the american heart association committee on cardiac imaging of the council on clinical cardiology and committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, Circulation 119, 1056-1065. [CrossRef] [PubMed] [Google Scholar]
  • Guo W.Y.,Wang G.J.,Wang P.,Chen Q.,Tan Y.,Cai L. (2010) Acceleration of diabetic wound healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells, Radiat. Res. 174, 467-479. [CrossRef] [PubMed] [Google Scholar]
  • Halle M.,Gabrielsen A.,Paulsson-Berne G.,Gahm C.,Agardh H.E.,Farnebo F.,Tornvall P. (2010) Sustained inflammation due to nuclear factor-kappa b activation in irradiated human arteries, J. Am. Coll. Cardiol. 55, 1227-1236. [CrossRef] [PubMed] [Google Scholar]
  • Halle M.,Hall P.,Tornvall P. (2011) Cardiovascular disease associated with radiotherapy: Activation of nuclear factor kappa-b, J. Int. Med. 269, 469-477. [CrossRef] [Google Scholar]
  • Harris E.E.,Correa C.,Hwang W.T.,Liao J.,Litt H.I.,Ferrari V.A.,Solin L.J. (2006) Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment, J. Clin. Oncol. 24, 4100-4106. [CrossRef] [PubMed] [Google Scholar]
  • Hauptmann M.,Mohan A.K.,Doody M.M.,Linet M.S.,Mabuchi K. (2003) Mortality from diseases of the circulatory system in radiologic technologists in the united states, Am. J. Epidemiol. 157, 239-248. [CrossRef] [PubMed] [Google Scholar]
  • Heckmann M.,Douwes K.,Peter R.,Degitz K. (1998) Vascular activation of adhesion molecule mrna and cell surface expression by ionizing radiation, Exp. Cell. Res. 238, 148-154. [CrossRef] [PubMed] [Google Scholar]
  • Heidenreich P.A.,Kapoor J.R. (2009) Radiation induced heart disease: Systemic disorders in heart disease, Heart 95, 252-258. [CrossRef] [PubMed] [Google Scholar]
  • Heissig B.,Rafii S.,Akiyama H.,Ohki Y.,Sato Y.,Rafael T.,Zhu Z.,Hicklin D.J.,Okumura K.,Ogawa H. et al. (2005) Low-dose irradiation promotes tissue revascularization through vegf release from mast cells and mmp-9-mediated progenitor cell mobilization, J. Exp. Med. 202, 739-750. [CrossRef] [PubMed] [Google Scholar]
  • Hooning M.J.,Botma A.,Aleman B.M.,Baaijens M.H.,Bartelink H.,Klijn J.G.,Taylor C.W., van Leeuwen F.E. (2007) Long-term risk of cardiovascular disease in 10-year survivors of breast cancer, J. Natl. Cancer Inst. 99, 365-375. [Google Scholar]
  • Houdart E.,Mounayer C.,Chapot R.,Saint-Maurice J.P.,Merland J.J. (2001) Carotid stenting for radiation-induced stenoses: A report of 7 cases, Stroke 32, 118-121. [CrossRef] [PubMed] [Google Scholar]
  • Hoving S., Heeneman S., Gijbels M.J., te Poele J.A.,Russell N.S.,Daemen M.J.,Stewart F.A. (2008) Single-dose and fractionated irradiation promote initiation and progression of atherosclerosis and induce an inflammatory plaque phenotype in apoe(-/-) mice, Int. J. Radiat. Oncol. Biol. Phys. 71, 848-857. [CrossRef] [PubMed] [Google Scholar]
  • Jahroudi N.,Ardekani A.M.,Greenberger J.S. (1996) Ionizing irradiation increases transcription of the von willebrand factor gene in endothelial cells, Blood 88, 3801-3814. [PubMed] [Google Scholar]
  • Little M.P.,Tawn E.J.,Tzoulaki I.,Wakeford R.,Hildebrandt G.,Paris F.,Tapio S.,Elliott P. (2008) A systematic review of epidemiological associations between low and moderate doses of ionizing radiation and late cardiovascular effects, and their possible mechanisms, Radiat. Res. 169, 99-109. [CrossRef] [PubMed] [Google Scholar]
  • Little M.P.,Tawn E.J.,Tzoulaki I.,Wakeford R.,Hildebrandt G.,Paris F.,Tapio S.,Elliott P. (2010) Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms, Radiat. Environ. Biophys. 49, 139-153. [Google Scholar]
  • McDonald S.,Rubin P.,Phillips T.L.,Marks L.B. (1995) Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems, Int. J. Radiat. Oncol. Biol. Phys. 31, 1187-1203. [CrossRef] [PubMed] [Google Scholar]
  • McGale P.,Darby S.C. (2005) Low doses of ionizing radiation and circulatory diseases: A systematic review of the published epidemiological evidence, Radiat. Res. 163, 247-257. [CrossRef] [PubMed] [Google Scholar]
  • McGeoghegan D.,Binks K.,Gillies M.,Jones S.,Whaley S. (2008) The non-cancer mortality experience of male workers at british nuclear fuels plc, 1946-2005, Int. J. Epidemiol. 37, 506-518. [Google Scholar]
  • Mettler F.A. Jr.,Thomadsen B.R.,Bhargavan M.,Gilley D.B.,Gray J.E.,Lipoti J.A.,McCrohan J.,Yoshizumi T.T.,Mahesh M. (2008) Medical radiation exposure in the u.S. In 2006: Preliminary results, Health. Phys. 95, 502-507. [CrossRef] [PubMed] [Google Scholar]
  • Metz-Flamant C.,Bonaventure A.,Milliat F.,Tirmarche M.,Laurier D.,Bernier M.O. (2009) [low doses of ionizing radiation and risk of cardiovascular disease: A review of epidemiological studies], Rev. Epidémiol. Santé Publique 57, 347-359. [Google Scholar]
  • Milliat F.,Francois A.,Isoir M. et al. (2006) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: Implication in radiation-induced vascular damages, Am. J. Pathol. 169, 1484-1495. [CrossRef] [PubMed] [Google Scholar]
  • Milliat F.,Francois A.,Tamarat R.,Benderitter M. (2008a) role of endothelium in radiation-induced normal tissue damages, Ann. Cardiol. Angeiol. (Paris) 57, 139-148. [CrossRef] [PubMed] [Google Scholar]
  • Milliat F.,Sabourin J.C.,Tarlet G.,Holler V.,Deutsch E.,Buard V.,Tamarat R.,Atfi A.,Benderitter M.,Francois A. (2008b) Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy, Am. J. Pathol. 172, 691-701. [CrossRef] [PubMed] [Google Scholar]
  • Miltenyi Z.,Keresztes K.,Garai I.,Edes I.,Galajda Z.,Toth L.,Illes A. (2004) Radiation-induced coronary artery disease in hodgkin’s disease, Cardiovasc. Radiat. Med. 5, 38-43. [CrossRef] [PubMed] [Google Scholar]
  • Mitchel R.E.,Hasu M.,Bugden M.,Wyatt H.,Little M.P.,Gola A.,Hildebrandt G.,Priest N.D.,Whitman S.C. (2011) Low-dose radiation exposure and atherosclerosis in apoe(-/-) mice, Radiat. Res. 175, 665-675. [CrossRef] [PubMed] [Google Scholar]
  • Modrall J.G.,Sadjadi J. (2003) Early and late presentations of radiation arteritis, Semin. Vasc. Surg. 16, 209-214. [CrossRef] [PubMed] [Google Scholar]
  • Mouthon M.A., Vereycken-Holler V., Van der Meeren A.,Gaugler M.H. (2003) Irradiation increases the interactions of platelets with the endothelium in vivo: Analysis by intravital microscopy, Radiat. Res. 160, 593-599. [CrossRef] [PubMed] [Google Scholar]
  • Paszat L.F.,Mackillop W.J.,Groome P.A.,Boyd C.,Schulze K.,Holowaty E. (1998) Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries, J. Clin. Oncol. 16, 2625-2631. [PubMed] [Google Scholar]
  • Peiro C.,Redondo J.,Rodriguez-Martinez M.A.,Angulo J.,Marin J.,Sanchez-Ferrer C.F. (1995) Influence of endothelium on cultured vascular smooth muscle cell proliferation, Hypertension 25, 748-751. [CrossRef] [PubMed] [Google Scholar]
  • Quarmby S.,Hunter R.D.,Kumar S. (2000) Irradiation induced expression of cd31, icam-1 and vcam-1 in human microvascular endothelial cells, Anticancer Res. 20, 3375-3381. [PubMed] [Google Scholar]
  • Quarmby S.,Kumar P.,Wang J.,Macro J.A.,Hutchinson J.J.,Hunter R.D.,Kumar S. (1999) Irradiation induces upregulation of cd31 in human endothelial cells, Arterioscler Thromb. Vasc. Biol. 19, 588-597. [CrossRef] [PubMed] [Google Scholar]
  • Richter K.K.,Fink L.M.,Hughes B.M.,Sung C.C.,Hauer-Jensen M. (1997) Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy? Radiother. Oncol. 44, 65-71. [CrossRef] [PubMed] [Google Scholar]
  • Rodel F.,Keilholz L.,Herrmann M.,Sauer R.,Hildebrandt G. (2007) Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy, Int. J. Radiat. Biol. 83, 357-366. [CrossRef] [PubMed] [Google Scholar]
  • Rodel F.,Hofmann D.,Auer J.,Keilholz L.,Rollinghoff M.,Sauer R.,Beuscher H.U. (2008) The anti-inflammatory effect of low-dose radiation therapy involves a diminished ccl20 chemokine expression and granulocyte/endothelial cell adhesion, Strahlenther Onkol. 184, 41-47. [CrossRef] [PubMed] [Google Scholar]
  • Ross R. (1999) Atherosclerosis – an inflammatory disease, N. Engl. J. Med. 340, 115-126. [CrossRef] [PubMed] [Google Scholar]
  • Rubin D.B., Drab E.A., Ts’ao C.H., Gardner D.,Ward W.F. (1985) Prostacyclin synthesis in irradiated endothelial cells cultured from bovine aorta, J. Appl. Physiol. 58, 592-597. [PubMed] [Google Scholar]
  • Russell N.S., Hoving S., Heeneman S., Hage J.J., Woerdeman L.A., de Bree R., Lohuis P.J., Smeele L., Cleutjens J., Valenkamp A. and others (2009) Novel insights into pathological changes in muscular arteries of radiotherapy patients, Radiother. Oncol. 92, 477-483. [CrossRef] [PubMed] [Google Scholar]
  • Seegenschmiedt M.H.,Micke O.,Willich N. (2004) Radiation therapy for nonmalignant diseases in germany. Current concepts and future perspectives, Strahlenther Onkol. 180, 718-730. [CrossRef] [PubMed] [Google Scholar]
  • Senkus-Konefka E.,Jassem J. (2007) Cardiovascular effects of breast cancer radiotherapy, Cancer Treat. Rev. 33, 578-593. [CrossRef] [PubMed] [Google Scholar]
  • Seppenwoolde Y., De Jaeger K.,Boersma L.J.,Belderbos J.S.,Lebesque J.V. (2004) Regional differences in lung radiosensitivity after radiotherapy for non-small-cell lung cancer, Int. J. Radiat. Oncol. Biol. Phys. 60, 748-758. [CrossRef] [PubMed] [Google Scholar]
  • Shapiro C.L.,Hardenbergh P.H.,Gelman R.,Blanks D.,Hauptman P.,Recht A.,Hayes D.F.,Harris J.,Henderson I.C. (1998) Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients, J. Clin. Oncol. 16, 3493-3501. [PubMed] [Google Scholar]
  • Shimizu Y., Kodama K., Nishi N., Kasagi F., Suyama A., Soda M., Grant E.J., Sugiyama H., Sakata R., Moriwaki H. et al. (2010) Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003, BMJ 340, b5349. [CrossRef] [PubMed] [Google Scholar]
  • Silverberg G.D.,Britt R.H.,Goffinet D.R. (1978) Radiation-induced carotid artery disease, Cancer 41, 130-137. [CrossRef] [PubMed] [Google Scholar]
  • Smith G.L.,Smith B.D.,Buchholz T.A.,Giordano S.H.,Garden A.S.,Woodward W.A.,Krumholz H.M.,Weber R.S.,Ang K.K.,Rosenthal D.I. (2008) Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy, J. Clin. Oncol. 26, 5119-5125. [CrossRef] [PubMed] [Google Scholar]
  • Stewart F.A., Heeneman S., Te Poele J.,Kruse J.,Russell N.S.,Gijbels M.,Daemen M. (2006) Ionizing radiation accelerates the development of atherosclerotic lesions in apoe-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage, Am. J. Pathol. 168, 649-658. [CrossRef] [PubMed] [Google Scholar]
  • Sugihara T.,Hattori Y.,Yamamoto Y.,Qi F.,Ichikawa R.,Sato A.,Liu M.Y.,Abe K.,Kanno M. (1999) Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation, Circulation 100, 635-641. [CrossRef] [PubMed] [Google Scholar]
  • Swerdlow A.J., Higgins C.D., Smith P., Cunningham D., Hancock B.W., Horwich A., Hoskin P.J., Lister A., Radford J.A., Rohatiner A.Z. and others (2007) Myocardial infarction mortality risk after treatment for hodgkin disease: A collaborative british cohort study, J. Natl. Cancer Inst. 99, 206-214. [CrossRef] [PubMed] [Google Scholar]
  • Taylor C.W.,Nisbet A.,McGale P.,Darby S.C. (2007) Cardiac exposures in breast cancer radiotherapy: 1950s-1990s, Int. J. Radiat. Oncol. Biol. Phys. 69, 1484-1495. [CrossRef] [PubMed] [Google Scholar]
  • Taylor C.W.,Povall J.M.,McGale P.,Nisbet A.,Dodwell D.,Smith J.T.,Darby S.C. (2008) Cardiac dose from tangential breast cancer radiotherapy in the year 2006, Int. J. Radiat. Oncol. Biol. Phys. 72, 501-507. [CrossRef] [PubMed] [Google Scholar]
  • Tribble D.L.,Barcellos-Hoff M.H.,Chu B.M.,Gong E.L. (1999) Ionizing radiation accelerates aortic lesion formation in fat-fed mice via sod-inhibitable processes, Arterioscler Thromb. Vasc. Biol. 19, 1387-1392. [CrossRef] [PubMed] [Google Scholar]
  • Tsoutsou P.G.,Koukourakis M.I. (2006) Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research, Int. J. Radiat. Oncol. Biol. Phys. 66, 1281-1293. [CrossRef] [PubMed] [Google Scholar]
  • Tukenova M., Guibout C., Oberlin O., Doyon F., Mousannif A., Haddy N., Guerin S., Pacquement H., Aouba A., Hawkins M. and others (2010) Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer, J. Clin. Oncol. 28, 1308-1315. [CrossRef] [PubMed] [Google Scholar]
  • van Luijk P.,Faber H.,Meertens H.,Schippers J.M.,Langendijk J.A.,Brandenburg S.,Kampinga H.H.,Coppes R.P. (2007) The impact of heart irradiation on dose-volume effects in the rat lung, Int. J. Radiat. Oncol. Biol. Phys. 69, 552-559. [CrossRef] [PubMed] [Google Scholar]
  • Veinot J.P.,Edwards W.D. (1996) Pathology of radiation-induced heart disease: A surgical and autopsy study of 27 cases, Hum. Pathol. 27, 766-773. [CrossRef] [PubMed] [Google Scholar]
  • Vereycken-Holler V.,Aigueperse J.,Gaugler M.H. (2002) Radiation effects on circulating and endothelial cell interactions studied by quantitative real-time videomicroscopy, Int. J. Radiat. Biol. 78, 923-930. [CrossRef] [PubMed] [Google Scholar]
  • Verheij M.,Dewit L.G., van Mourik J.A. (1995) The effect of ionizing radiation on endothelial tissue factor activity and its cellular localization, Thromb. Haemost. 73, 894-895. [PubMed] [Google Scholar]
  • Verheij M.,Dewit L., van Mourik J.A. (1997) Radiation-induced von willebrand factor release, Blood 90, 2109-2110. [PubMed] [Google Scholar]
  • Yamada M.,Wong F.L.,Fujiwara S.,Akahoshi M.,Suzuki G. (2004) Noncancer disease incidence in atomic bomb survivors, 1958-1998, Radiat. Res. 161, 622-632. [CrossRef] [PubMed] [Google Scholar]
  • Zhang C.,Tan Y.,Guo W.,Li C.,Ji S.,Li X.,Cai L. (2009) Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation, Am. J. Physiol. Endocrinol. Metab. 297, E1366-1377. [CrossRef] [PubMed] [Google Scholar]
  • Zhang C.,Jin S.,Guo W.,Li C.,Li X.,Rane M.J.,Wang G.,Cai L. (2011) Attenuation of diabetes-induced cardiac inflammation and pathological remodeling by low-dose radiation, Radiat. Res. 175, 307-321. [CrossRef] [PubMed] [Google Scholar]
  • Zhou Q.,Zhao Y.,Li P.,Bai X.,Ruan C. (1992) Thrombomodulin as a marker of radiation-induced endothelial cell injury, Radiat. Res. 131, 285-289. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.