Molecular-Genetic and Epidemiologic Examination of Personnel Subjected to Occupational Irradiation

¹ Russian Federal Nuclear Center – VNIIEF, 37, Mira av., 607190 Sarov, Nizhni Novgorod region, 607190 Sarov, Russian Federation
² Vavilov Institute for General Genetics, Russian Ac, 3, Gubkin str., 117809 Moscow, Russia, 117809 Moscow, Russian Federation
³ Research Center for Medical Genetics, Russian Acad, 1, Moscvorechie str., 115478 Moscow, Russia, 115478 Moscow, Russian Federation
⁴ N.N. Semenov Institute of Chemical Physics RAS, Kosygin str. 4, 119991 Moscow, Russian Federation
⁵ Department of Genetics, University of Leicester, University Road, LE1 7RH Leicester, United Kingdom
⁶ Clinical hospital-50 (CH-50), 607190, 37, Mira av., Sarov, Nizhni Novgorod regi, 607190 Sarov, Russian Federation

Abstract

It is given an evaluation of the genetic polymorphisms (Hp, Tf, Gc; 6-PGD, EsD, ACP, PGM1, microsatellite loci CSF1PO и F13AO1, detoxicating genes GSTT1, GSTM1 and GSTP1), individual radiosensitivity (by the criterion of ribosome gene fragments) and DNA-damage rate (Comet-assay) in two cohorts comprised by VNIIEF personnel subjected chronically to gamma-neutron ionizing radiation and to β-radiation of Tritium in comparison with the effects in non-irradiated cohort. There are discussed data on the influence of the occupational irradiation, age and genotype on the rate of structural genome damage, as well as on the activity of the human repair system activity and health status.