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Accueil Tous les numéros Volume 52 / Numéro 4 (October-December 2017) Radioprotection, 52 4 (2017) 231-240 Full HTML

Table 3

Epidemiology studies conducted to identify a link between diagnostic radiations and breast cancer risk among BRCA1/2 carriers: breast attributed doses per radiological procedure.

Study Gene mutation Study design
(n women)		 Type of
Diagnostic procedure
Risk		 Breast attributed dose per radiological exam (mGy) Association with
Breast cancer risk
Positive +
Negative −
Goldfrank, 2006 (Goldfrank et al., 2006) BRCA1/2 Case-control
(34–128)		 Only mammography
Numbers of mammograms
BRCA1 OR = 1.08 (p = 0.003)		 NA + for BRCA1
Narod, 2006 (Narod et al., 2006) BRCA1/2 Case-control
(1600–1,600)		 Only mammography
Age at 1st screening mammography
OR = 1.03 (95%CI = 0.85–1.25)		 NA –
Andrieu, 2006 (Andrieu et al., 2006) BRCA1/2 Retrospective
cohort
(1,601)		 Only Chest Radiography
before age 20 RR = 4.6 (95% CI = 2.2–10.9)
before age 40 RR = 2.0 (95% CI = 1.2–2.9)		 0.5 +
Gronwald, 2008 (Gronwald et al., 2008) BRCA1 Case-case
BRCA+ vs. BRCA-
(138–158)		 Only Chest Radiography
before age 30
OR = 1.8 (95% CI 1.2–2.9;
p = 0.01)		 NA +
Lecarpentier, 2011 (Lecarpentier et al., 2011) BRCA1/2 Case-control
(10–365)		 Only Chest radiography
HR = 4.29 (95% CI 2.09–8.81)		 NA +
Pijpe, 2012 (Pijpe et al., 2012) BRCA1/2 Retrospective
cohort
(1,993)		 Any exposure involving chest or shoulders***
Before age 20, HR = 3.16 (95% CI 1.19–8.36) for 6.6 mGy
Before age 3, HR = 3.84 (95% CI 1.67–8.79) for ≥ 17 mGy		 Fluoroscopy: 5–10*
Radiography: 0.5
Mammography: 3.5–18.6*
Computed Tomography **: 20		 +
John, 2013 (John et al., 2013) BRCA1/2 Case-control
(271–456)		 Only Chest Radiography
OR = 2.49 (95%CI = 1.82–3.40) for tuberculosis
OR = 2.19 (95%CI = 1.38–3.47) for pneumonia		 NA –
Giannakeas, 2014 (Giannakeas et al., 2014) BRCA1/2 Retrospective
cohort
2,346		 Only mammography
BRCA1 HR = 0.79 (95% CI = 0.53–1.19 p = 0.26)
BRCA2 HR = 0.90 (95% CI = 0.35–2.34 p = 0.83)		 NA –

RR = Relative Risk; OR = Odds Ratio; HR = Hazard Ratio; CI = Confidence Interval; NA = Not Available.

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