Volume 40, May 2005ECORAD 2004
|Page(s)||S229 - S234|
|Published online||17 June 2005|
Developing experimental protocols for chronic irradiation studies: The application of a good practice guide framework
School of Biological Sciences, University of Liverpool, Liverpool L69 3BX, UK
2 Environment Agency, Knutsford Road, Warrington WA4 1HG, UK
3 Swedish Radiation Protection Authority (SSI), 171 16 Stockholm, Sweden
A recent review of radiation effects data highlighted that information on the effects of low-dose, chronic exposure was, at best, fragmentary. These data are required to define the dose effect relationships, which must underpin assessments of the impact of ionising radiation on biota. In response, four Good Practice Guides (GPGs) have been produced as part of a protocol development framework that aims to harmonise experimental approaches, with a view to ensuring that appropriate endpoint data are collected and reliable dose effect relationships determined. The GPGs cover test species selection, endpoint selection, radiation exposure and experimental design considerations. A key guides researchers through the GPGs and the decisions made are recorded on a pro-forma, which is the basis of the experimental protocol. This paper describes the first application of the framework to a radiation effects study. The framework has been adopted by the UK Environment Agency as a document upon which future Agency-funded experimental work in this field will be based. It is hoped that the framework will gain acceptance in the wider scientific community and enable knowledge gaps to be addressed, in order that successful protection of non-human biota can be demonstrated.
© EDP Sciences, 2005
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