Article

Review of operational indications on the design of facilities for radiopharmaceutical manufacturing in italy^☆

¹ INAIL – Italian Workers Compensation Authority, via di Fontana Candida, 1, Monte Porzio Catone, Rome 00078, Italy
² ENEA – Italian National Agency for New Technologies, Energy and Sustainable Economic Development, via E. Fermi 45, Frascati, Rome 00044, Italy
³ Medical Physicist, via della Bufalotta 845, Rome 00138, Italy
⁴ Umberto I University Hospital, Viale del Policlinico 155, Rome 00161, Italy

^* Corresponding author: gianmarco.contessa@enea.it

Received: 30 July 2020
Accepted: 28 September 2020

Abstract

Purpose. In this article, the authors propose useful operational indications to approach in the best possible way the issues concerning the design of a facility for manufacturing radiopharmaceuticals, with focus on organizational and safety aspects. Methods. Several documents produced by authoritative bodies, national and international scientific institutions and associations were examined and referenced, to the purpose of reviewing all available information in the field. Results. Indications are gathered for the design stage, including the organization of accesses and routes and characteristics and requirements of premises and systems. Conclusions. Main goal is to guide the reader in evaluating and choosing the most suitable features and equipment to limit the risks due to ionizing radiation and to prevent contamination of the workers and the environment.