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Table 1

Summary of the top 15 biological processes from gene set enrichment analysis.

Process Genes in query set Total genes in genome FDR corrected hypergeometric P value* Genes
Positive regulation of gene expression (BP) 10 104 6.80E-07 SLC6A4, CD44, TWIST1, PLAUR, AVPR2, NCOA3, MYLK2, CSF2, CALR, KIT
Blood coagulation (BP) 18 457 9.60E-07 THPO, PPBP, L1CAM, PROS1, IFNA1, PIK3CA, SERPINC1, SERPINB2, PLAUR, TP53, F11R, F8, PIK3CG, PIK3CB, TIMP1, BCAR1, SERPINE1, PIK3R5
Signal transduction (BP) 29 1176 1.22E-06 RASGRF1, NR2E3, KCNIP3, OPTN, NRP1, APOL3, COL4A3BP, PIK3CA, NR1I2, ARTN, PLAUR, ADCY3, ARL2BP, ESR1, GJA1, ARFRP1, HINT1, PIK3CB, OPN1LW, KIT,LTBR, PIK3CD, CXXC5, BCAR1, ANGPTL4, PAG1, CREBBP, IMPA1, PDGFRB
Transport (BP) 19 604 5.10E-06 RBP5, NCBP1, DBI, CLCN2, SLC25A47, APOL3, COL4A3BP, SERPINA5, CACNA1B, SLC25A33, RBM8A, GJA1, SLC6A8, CNGB1, MTCH1, SLC25A32, SLC12A3, PARP4, MTCH2
Axon guidance (BP) 14 307 5.25E-06 L1CAM, COL9A1, NRP1, FARP2, SCN8A, ARTN, COL5A2, PTPRC, PTPRA, CACNA1F, SEMA3A, COL9A2, MYL6, COL5A1
Cell adhesion (BP) 18 556 6.55E-06 L1CAM, COL9A1, AMBP, CD44, DSC3, NRP1, DSC2, RPSA, F11R, HABP2, F8, CTNND1, PIK3CB, COL11A2, LAMC2, BCAR1, COL5A1, COMP
Platelet activation (BP) 11 234 7.60E-05 THPO, PPBP, SAA1, PROS1, PIK3CA, F8, PIK3CG, PIK3CB, TIMP1, SERPINE1, PIK3R5
Cell junction assembly (BP) 7 90 0.000247 F11R, SFTPA2, JUP, CTNND1, SFTPA1, LAMC2, KRT5
Negative regulation of apoptotic process (BP) 11 272 0.000257 CD44, PLAUR, TP53, LEP, PIK3CG, CFLAR, CSF2, TIMP1, ANGPTL4, SERPINE1, JTB
Intracellular receptor mediated signaling pathway (BP) 5 32 0.000277 NR0B1, NR2E3, NR1I2, PPARA, PTGER3
Negative regulation of transcription from RNA polymerase II promoter (BP) 13 416 0.000341 NR0B1, KCNIP3, TWIST1, FOXD3, PPARA, TP53, LEP, JUP, IKZF1, ATN1, CALR, TCEAL1, CREBBP
Regulation of proteolysis (BP) 5 37 0.000359 SERPINA5, SERPINC1, SERPINB2, PLAUR, SERPINB3
Acute-phase response (BP) 5 37 0.000359 SAA1, F8, REG3G, REG3A, SAA4
Negative regulation of endopeptidase activity (BP) 6 67 0.00039 PROS1, SERPINA5, SERPINC1, SERPINB2, SERPINE1, SERPINB3
Cell migration (BP) 7 105 0.000432 NRP1, JUP, ATN1, BCAR1, COL5A1, PARP9, PDGFRB

* P value less than 0.05.

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