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Radioprotection 2005, Vol. 40, n° Suppl. 1, pages S151 à S155
DOI: 10.1051/radiopro:2005s1-024
Changes in oxidative stress parameters in fish as response to direct uranium exposure
A. Buet, S. Barillet and V. CamilleriLaboratory of Radioecology and Ecotoxicology, Institute for Radioprotection and Nuclear Safety, DEI/SECRE/LRE, Cadarache Center, Bd. 186, BP. 3, St-Paul-lez-Durance, France,
e-mail: a.buet@free.fr
Abstract
The objectives of the present work were (1) to estimate the bioaccumulation of natural uranium (U) in a representative freshwater fish and (2) to assess the response of parameters involved in the defense against reactive oxygen species, in relation with the metal concentration and the exposure duration. Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to a range of U concentrations in water (20, 100 and 500 
g U l-1) during 10 days. The activity of antioxidant enzymes superoxide dismutases (SOD) and catalase were measured in trout liver. In parallel, U analysis were performed in water and in trout gills. A significant accumulation
of U occurred in trout gills in relation with the concentrations of U in water. SOD and catalase activities were both decreased by the exposure to U. U seemed to partly inhibit the antioxidant system of trout, indicating a potential enlarged sensitivity of exposed fish to oxidative damages.
© EDP Sciences 2005